Sake kunna cutar HIV-1 ta Latent Bacterium ta Periodontopathic Bacterium

Kwayoyin da suka kamu da kwanan nan suna ɗauke da kwayoyin halittar DNA na lardi na HIV-1 da farko an haɗa su cikin heterochromatin, suna ba da damar dagewar proviruses na shiru.Hypoacetylation na sunadaran histone ta histone deacetylases (HDAC) yana da hannu a cikin kiyaye jinkirin HIV-1 ta hanyar murƙushe rubutun hoto.Bugu da kari, cututtuka na periodontal, wanda ke haifar da ƙwayoyin cuta na polymicrobial subgingival ciki har da Porphyromonas gingivalis, suna cikin cututtukan da suka fi dacewa da ɗan adam.Anan mun nuna tasirin P. gingivalis akan kwafin HIV-1.Wannan aikin zai iya zama abin ƙididdigewa ga ƙaƙƙarfan al'adun ƙwayoyin cuta amma ba ga sauran abubuwan ƙwayoyin cuta kamar fimbriae ko LPS ba.Mun gano cewa an dawo da wannan aikin da ke haifar da kwayar cutar HIV a cikin ƙananan ƙwayoyin ƙwayoyin cuta (<3 kDa) na al'ada mai girma.Mun kuma nuna cewa P. gingivalis yana samar da babban adadin butyric acid, yana aiki azaman mai hanawa mai ƙarfi na HDACs kuma yana haifar da histone acetylation.Gwaje-gwajen rigakafi na Chromatin ya bayyana cewa hadadden ma'aunin da ke dauke da HDAC1 da AP-4 an raba shi da mai tallata dogon zango na HIV-1 akan karfafawa tare da al'adar kwayan cuta mai ƙarfi tare da haɗin gwiwar histone acetylated da RNA polymerase II.Ta haka ne muka gano cewa P. gingivalis na iya haifar da sake kunnawa na HIV-1 ta hanyar gyare-gyare na chromatin kuma cewa butyric acid, daya daga cikin kwayoyin kwayoyin halitta, yana da alhakin wannan sakamako.Wadannan sakamakon sun nuna cewa cututtuka na lokaci-lokaci na iya zama abin haɗari ga sake kunnawa HIV-1 a cikin mutanen da suka kamu da cutar kuma zai iya taimakawa wajen yada kwayar cutar.